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金种子酒前三季亏损扩大 净利暴跌4507.33%

時間: 2017年05月18日 | 作者: admin | 來源: 未知

撰文/播音 Christopher Intagliata

翻譯 Meatle

審校 邰倫

 

 

One of the great promises of stem-cell biology is to use a patient’s own cells as a template to build a real, working organ or tissue in the lab. One prime example: a treatment fordiabetes by turning stem cells into working pancreatic beta cells, which release insulin. 

干細胞技術的一大運用,就是利用病人的細胞作為模板,在實驗室造出一個真正能活體的器官組織。一個典型的例子是,糖尿病一種療法將干細胞轉化為功能正常能產生胰島素的β胰腺細胞。

"The existing beta cells that our lab and others had created were 90 percent of the way there. But 90 percent still means not functional." Ron Evans, a molecular biologist at the Salk Institute. 

我們的和其他研究組的實驗室現存的β細胞能夠達到真實細胞的90%。然而90%仍然不足以使到這些測試細胞能夠正常起效。索科生物研究所(the Salk Institute)的分子生物學家,龍?埃文斯(Ron Evans)說。

Evans compares the stem-cell-derived beta cells they first made to a darkened room. "If you walk into that room, there may be everything in it that you need to be a complete room, with furniture and chairs and everything else. But it's dark. And the key is: what do you need to turn on the light?"

埃文斯將它們起初制造的β細胞比喻成黑房間。試想一下,那間房子里你生活所需的一切,比如像桌子家具。然而房間里面一片漆黑問題在于,如何燈打開

That light switch, Evans discovered, is a gene—called estrogen-related receptor gamma. Flip it on, and it activates a genetic circuit that ramps up mitochondria production, powers up the cell, and endows the almost-functional beta cells with the ability to sense glucose and release insulin in response.

埃文斯所發現的燈開關”是一段被稱為雌激素關聯受體γ(estrogen-related receptor gamma)的基因。將它啟動就能接通一段基因回路,使到細胞內的線粒體全速運行從而點亮整個房間”——這些接近完全的細胞能夠察覺到血糖波動,進而釋放出胰島素。

Evans's team recently used that trick to transform stem cells into beta cells that worked just like they would in a healthy pancreas. When they transplanted those cells into mice with a mouse version of diabetes, blood glucose fell to normal levels in half the rodents. The results are in the journal Cell Metabolism. [Eiji Yoshihara et al, ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells]

埃文斯的團隊使用上述的手法,使到干細胞轉化為能像正常胰腺細胞一樣工作的β細胞。之後他們將這些細胞移植到患有糖尿病的小鼠身上,這些接受移植的小鼠有半數血糖恢復了正常。該項研究發表在細胞代謝(Cell Metabolism)

Next, Evans says he'll replicate the test in diabetic primates. "Primates get diabetes in a fashion that's very similar to people. So if it works in a primate, very high probability that it's going to work in people." If it does, we might someday replace a shot of insulin with a shot of cells.

埃文斯認為,下一步他將在靈長類身上重復這個實驗。靈長類患上糖尿病的方式與人類相當類似因此如果這種療法在靈長類中行得通,那麼這種療法也有相當大的可能性治愈人類。”若是這樣,治療糖尿病人,有朝一日只需注射一劑細胞,而不是胰島素。

 

 

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